The genetic architecture of vitiligo

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Genetic Epidemiology and Heritability of Vitiligo

1.1 Prevalence & incidence The population prevalence of vitiligo ranges from 0.1% to 2% and shows a wide variability among ethnic groups (Bolognia et al., 1998; Hann and Nordlund, 2000). Whereas the estimated population prevalence of vitiligo is approximately 0.38% for Caucasians in the United States and Northern Europe (Howitz et al., 1977), vitiligo affects 0.19% of the population in China (X...

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Association of CYP2C9 Genetic Variants with Vitiligo

BACKGROUND Vitiligo is a depigmenting skin disorder in which genetic factors play an important role. OBJECTIVE To examine the association of CYP2C9 (*) 1/(*) 2/(*) 3 gene polymorphism with vitiligo. METHODS In this case controlled study, 95 Saudi patients with vitiligo (50 men and 45 women), with a mean age of 27.3 years, were analyzed. Patients were compared to 86 healthy controls from the...

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Effects of medicinal plants on the Vitiligo

Vitiligo is a skin disease that has been known about for at least 5000 years, but little has been done to understand its causes or to evaluate possible treatment. It is not a painful condition and perhaps that is why it is often trivialized and left untreated. Vitiligo is characterized by depigmented areas of skin. There are several different theories One theory is that people develop antibodie...

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Vitiligo is an autoimmune disease with a strong genetic component, characterized by areas of depigmented skin resulting from loss of epidermal melanocytes. Genetic factors are known to play key roles in vitiligo through discoveries in association studies and family studies. Previously, vitiligo susceptibility genes were mainly revealed through linkage analysis and candidate gene studies. Recent...

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ژورنال

عنوان ژورنال: Pigment Cell & Melanoma Research

سال: 2019

ISSN: 1755-1471,1755-148X

DOI: 10.1111/pcmr.12848